{"id":65738,"date":"2026-04-10T08:00:41","date_gmt":"2026-04-10T06:00:41","guid":{"rendered":"https:\/\/mivisalud.com\/blog\/myths-and-truths-about-the-safety-and-efficacy-of-medical-ozone-in-the-treatment-of-pain\/"},"modified":"2026-04-14T10:29:20","modified_gmt":"2026-04-14T08:29:20","slug":"myths-and-truths-about-the-safety-and-efficacy-of-medical-ozone-in-the-treatment-of-pain","status":"publish","type":"post","link":"https:\/\/mivisalud.com\/en\/blog\/myths-and-truths-about-the-safety-and-efficacy-of-medical-ozone-in-the-treatment-of-pain\/","title":{"rendered":"Myths and truths about the safety and efficacy of medical ozone in the treatment of pain."},"content":{"rendered":"<p>03The use of medical ozone in the treatment of chronic pain is an expanding practice<br \/>\nthat, although it has institutional backing in countries such as Spain, is still surrounded by<br \/>\ncontroversy and contradictory perceptions. The following are the main myths and<br \/>\ntruths about its safety and efficacy based on the sources provided. <\/p>\n<p><strong>Myths about medical ozone<\/strong><br \/>\n&#8211; <strong>&#8220;Ozone is always toxic to humans&#8221;:<\/strong> This is one of the most common misconceptions<br \/>\n. Although ozone is a toxic gas when inhaled, as it damages lung tissue<br \/>\nand airways, its medical use is safe when administered by appropriate<br \/>\nroutes (infiltrative, topical or systemic) and in controlled doses. Medical ozone is never<br \/>\ninhaled and consists of a mixture where ozone represents at most 5% and<br \/>\noxygen 95%.  <\/p>\n<p>&#8211; <strong>&#8220;There is no scientific evidence to support its use&#8221;<\/strong>: Although some sectors<br \/>\nconsider it &#8220;quackery&#8221;, there are many meta-analyses and systematic reviews in<br \/>\nindexed journals that support its efficacy, especially for the treatment of lumbar disc herniation<br \/>\nand knee osteoarthritis. In fact, in Spain it has been officially included<br \/>\nin the portfolio of services of pain units since 2011.<br \/>\nTruths about its efficacy and safety. <\/p>\n<p><strong>&#8211; Efficacy in spine and joint pathology:<\/strong> The truth is that ozone therapy has<br \/>\ndemonstrated very good results when used as a &#8220;discolytic&#8221; agent in herniated<br \/>\ndiscs, but with the advantage of being an outpatient and minimally invasive treatment.<br \/>\nIt acts by &#8220;mummifying&#8221; the nucleus pulposus, which reduces the volume of the disc<br \/>\nand decreases nerve compression. In osteoarthritis of the knee, it has a high level of evidence<br \/>\n, improving pain and function. <\/p>\n<p>&#8211; <strong>Biological mechanism of action:<\/strong> Ozone acts by inducing a controlled &#8220;micro-oxidation&#8221;<br \/>\nthat activates the cellular antioxidant system (NRF2 pathway), blocks inflammatory pathways<br \/>\nand promotes the regeneration of tissues such as cartilage. It has analgesic,<br \/>\nanti-inflammatory and antiseptic properties and improves tissue oxygenation. <\/p>\n<p>&#8211; <strong>High safety profile:<\/strong> Assuming that it must be performed by<br \/>\ntrained professionals and with precision generators for medical use, the risk of adverse effects is<br \/>\nextremely low (approximately 0.0007% in systemic applications such as<br \/>\nautohemotherapy). Most of the serious complications reported in the literature are<br \/>\ndue to bad practices, such as direct intravenous injection (prohibited) or infections<br \/>\ndue to lack of hygiene in the puncture, and not to the ozone molecule itself. <\/p>\n<p>&#8211; <strong>Specific contraindications:<\/strong> It is a medical truth that ozone therapy is<br \/>\nstrictly contraindicated in patients with favism (G6PD enzyme deficiency), since<br \/>\ncan cause hemolysis. It is also not recommended in cases of uncontrolled hyperthyroidism<br \/>\n, pregnancy and severe cardiovascular pathologies.<br \/>\nIn conclusion, medical ozone is neither a universal therapy nor risk-free, but rigorous studies<br \/>\nconfirm that it is a safe and effective tool for the management of musculoskeletal and pain diseases<br \/>\n, provided that standardized protocols are followed and certified medical technology<br \/>\nis used. <\/p>\n<p>&nbsp;<\/p>\n<p><strong>Author:<\/strong> <a href=\"https:\/\/mivisalud.com\/en\/physician\/enrique-del-cojo-peces\/\">Kike del Cojo<\/a><\/p>\n<p>Director of the MIVI C\u00e1ceres Pain Unit<\/p>\n","protected":false},"excerpt":{"rendered":"<p>03The use of medical ozone in the treatment of chronic pain is an expanding practice that, although it&hellip;<\/p>\n","protected":false},"author":11,"featured_media":65736,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[979,1295],"tags":[],"class_list":["post-65738","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pain-treatments","category-treatments"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u25b7 Myths and truths about the safety and efficacy of medical ozone in the treatment of pain. | Mivi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mivisalud.com\/en\/blog\/myths-and-truths-about-the-safety-and-efficacy-of-medical-ozone-in-the-treatment-of-pain\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" 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